What is SCC risk?

The development of SCC is influenced by a multitude of risk factors, with immunosuppression being a notable contributor. Conditions that weaken the immune system, such as HIV/AIDS or certain medications, can increase the likelihood of developing this malignancy.

Chronic wounds, another risk factor, can provide a conducive environment for the unchecked proliferation of abnormal cells, leading to the development of SCC. Additionally, individuals with fair skin are more susceptible to the harmful effects of UV radiation, further elevating their risk.

Males and older adults are also more prone to developing SCC, with the incidence increasing with age. Moreover, several genetic syndromes can predispose individuals to this type of cancer, highlighting the importance of genetic factors in its etiology.

Environmental exposures, particularly UV radiation, play a crucial role in the development of SCC. Prolonged sun exposure without adequate protection can damage skin cells, initiating the process of carcinogenesis. A personal history of SCC also increases the risk of recurrence or the development of additional lesions.

Squamous cell carcinoma (SCC) holds a prominent position among cutaneous malignancies in the United States, ranking second in prevalence. This form of cancer originates from the abnormal growth of squamous cells, which are flat cells found in the outer layer of the skin.