I am conducting research on the protein inhibitor related to activated STAT1. I need to know the specific protein inhibitor that can effectively target and inhibit the activated form of STAT1.
7 answers
CryptoMaven
Sat Nov 02 2024
Protein inhibitors of activated STATs, known as PIAS, play a crucial role in regulating the signaling pathways of STAT proteins.
CherryBlossomFalling
Sat Nov 02 2024
By binding to phosphorylated STAT dimers, PIAS proteins effectively block the recognition of DNA by these dimers.
SunlitMystery
Sat Nov 02 2024
This binding action subsequently inhibits the STAT-mediated signaling cascades, which are essential for cellular responses to various stimuli.
Valentino
Sat Nov 02 2024
Shuai's research in 2000 highlighted the significance of PIAS in modulating STAT activity.
CryptoLordess
Fri Nov 01 2024
Among the various PIAS proteins, PIAS1 has been identified as a specific binding partner of activated STAT1.